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The paper deals with the most appropriate variant of the CDP seismic exploration technique for<br>carrying out the regional works of federal significance. Efficiency of the technique for<br>investigating a geological section down to and including horizons of the upper mantle (the Moho<br>discontinuity) is demonstrated by an example of the regional Orenburg-Manych profile passing<br>along the marginal scarp in the inner part of the Pre-Caspian depression. The velocity<br>characteristics of the section are estimated for the basic lithologic-sratigraphic complexes,<br>including the strata confined between the Moho discontinuity and crystalline basement.