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This study focuses on the evolution of the fluid-rock interactions during the reservoir production of the Rousse field, followed by the injection of hypothetical 100000 tonnes of CO2. The study of reactive flow continues post-injection up to 10000 years. 0D numerical simulations with geochemical software Arxim were performed on several mineral assemblages to study the geochemical reactions due to the variation of reservoir pressure between the beginning and the end of the production as well as the impact of the CO2 injection. These simulations were supplemented by 3D numerical triphasic compositional reactive simulations at the reservoir scale with CooresTM simulator.