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The present work present complete a procedure to properly set a regional inverse gravimetric problem. In particular, given a target (e.g. Moho depth or depth to basement) and the area of interested, we propose a methodology to choose the most appropriate functional of the gravity field to be used (i.e. gravity anomaly vs second radial derivative). Once the functional is chosen, we also develop a simple method to investigate whether the planar approximation (classical adopted) is sufficient or a more sophisticated spherical approximation is required to perform the inversion. The methodology is tested on a real case in the Central-Mediterranean area where a set of other additional parameters, namely the optimal spatial resolution of the volume to be inverted, the depth to which density anomalies should be modelled and the border required to avoid mismodelling error are also computed.