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The Lodève Late Carboniferous-Permian basin provides a particularly relevant example of a small scale polyphased metallogenic reactor from source to sink that can help to better target hidden/deep buried strategic resources in post-orogenic basins. Here, three mains mineralized stages are evidenced, sourced by the leaching of intra- to peri-basinal metal-bearing volcano-clastic material. In this model, uranium ore deposit because of its high mobility dissociates very early from the other metals and is submitted to successive remobilization under basinal oxidizing fluids up to the final economic trapping close to E-W fault corridor in the northern part of the basin. The main barite-sulphides mineralization is interpreted as an original Mississippi Valley Type (MVT) ore deposit governed by the dewatering of interstitial metal-rich overpressured fluids toward the margin of the basin with a local fault-valve behaviour. Finelly, these barite-suphides ore deposits were partly reworked and tapped by bacterial reduction processes in meteoric karst during the Middle Triassic flooding.