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This study presents an integrated 3D crustal model of the Southern Apennines, a key area within this region, developed at a spatial resolution of 5×5×1 km3. The model synthesizes a wide array of geological and geophysical datasets, including stratigraphic well logs, lithological maps, seismic tomography, gravity and magnetic data, and thermal-petrophysical constraints. These inputs were rigorously processed to ensure spatial consistency and to capture depth-dependent properties such as thermal gradients and P-wave velocity variations. The model delineates major lithological units, from sedimentary covers and carbonate platforms to the crystalline basement, and identifies key intra-crustal discontinuities, extending down to the Moho. Validation against independent borehole and geophysical data confirms its accuracy. Beyond its scientific value, the model supports thermo-rheological analysis to investigate brittle-ductile transitions relevant to seismic risk, contributing to the TRHAM project (PRIN2022 PNRR).