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This study examined the interactions between light crude oil and three gases—hydrogen, methane, and a natural gas mixture—under subsurface-relevant conditions (500–5000 psi, 30–90 °C). Changes in oil properties due to gas saturation were evaluated alongside interfacial behavior, using interfacial tension (IFT) measurements performed at 90 °C and across a wide pressure range. Results revealed that oil viscosity and density varied notably with pressure, temperature, and gas type. The natural gas mixture and CH₄ demonstrated greater solubility in oil compared to H₂, with the gas mixture producing the most pronounced reduction in viscosity and density—primarily due to its CO2 content. H2-saturated oil exhibited the highest viscosity and intermediate density, while CH4 caused moderate reductions in both properties. IFT measurements further confirmed CO2’s effect in enhancing miscibility, as the gas mixture showed the lowest IFT and minimum miscibility pressure (MMP). In contrast, H2 exhibited significantly higher IFT values, reflecting poor miscibility and a requirement for unrealistically high pressures to achieve full dissolution in oil. These findings indicate that hydrogen dissolution in crude oil under reservoir conditions is limited, suggesting that losses during UHS in depleted oil reservoirs would be minimal. Consequently, such reservoirs remain promising candidates for large-scale hydrogen storage.